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GMO Golden Rice Offers No Nutritional Benefits Says FDA

GMO Golden Rice Offers No Nutritional Benefits Says FDA

Golden Rice grain compared to white rice grain in screenhouse of Golden Rice plants. Photo: International Rice Institute.

The biotech industry and its supporters have promoted GMO Golden Rice for decades as an urgently needed solution to vitamin A deficiency.

But, in a surprising twist, the US Food and Drug Administration (FDA) has concluded its consultation process on Golden Rice by informing its current developers, the International Rice Research Institute (IRRI), that Golden Rice does not meet the nutritional requirements to make a health claim.

Golden Rice refers to GMO rice plants modified to produce beta-carotene (also called provitamin A) in their grain. This latest version of Golden Rice contains three added genes. Two specify enzymes in the β-carotene biosynthesis pathway, and are taken from bacteria and maize. The third specifies a (non-antibiotic) selectable marker protein used in the modification process (Paine et al. 2005).

First described in the scientific literature over 18 years ago by public sector researchers (Ye et al. 2000), various public and private sector iterations of Golden Rice have subsequently been produced (Bollenidi et al. 2014). These represent repeated efforts to increase beta-carotene levels, while still maintaining plant vigor and yield.

The Golden Rice version submitted to FDA by IRRI, called event GR2E, is the only Golden Rice to have ever been submitted for regulatory approval. In 2017, it was approved for import by regulators in Australia, New Zealand, and Canada. Originally developed by Syngenta, Golden Rice GR2E is now funded by the Gates Foundation.

The letter containing FDA’s statement on GR2E’s lack of nutritional benefit was posted on May 25th, 2018 (FDA 2018b).

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